Abstract

To study clinical profile of organophosphate compound poisoning with special reference to electrocardiographic changes and electrolyte derangements. Methodology: There are 200 cases of organophosphorus compound poisoning were admitted to Medicine wards in Government General Hospital, Kakinada during study period. But after applying inclusion and exclusion criteria, 100 cases were left out, which meets the criteria and have been selected for the present study. Results: In this study, 100 cases of poisoning by an organophosphorus compound were clinically examined, and the following observations were made. The age group between 21 and 30 is the most vulnerable (44%). The ratio of men to women is 4.5:1. The oral route of intake was used with all patients. The type of the compound that is an organophosphate was identified (64%) and unidentified (36%). The most prevalent organophosphate compound among the identified group was Monocrotophos (36%) and it was followed by Dimethoate (Roger) (19%), Diazinon (6%), Melathion (2%), and Parathion (1%). The majority of the patients (55%) were admitted to the hospital within 2-4 hours of ingesting an organophosphorus compound. The majority (54%) of patients spent 6–10 days in the hospital overall. Present symptoms include blurred vision (46%), sweating (44%), salivation (42%), vomiting (48%), and lacrimation (38%). Tachypnoea (96%), altered consciousness (78%), constricted pupils (52%), and fasciculation (41%), which are common symptoms. Of the 100 patients in this study, 20 patients passed away. Only 9 patients with normal ECGs and 11 (55%) with a prolonged QTc interval were among the deceased patients. ECG changes have a poor prognosis and are closely correlated with an increase in complication incidence. Organophosphorus compounds have variable cardiovascular effects that frequently shift over the course of poisoning. Continuous cardiac monitor- ing is required because of ECG changes like QTc prolongation, which can be danger- ous.

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