Abstract

Antithrombotic therapies represent a cornerstone in the management of patients with Acute coronary syndrome (ACS). The combination of clopidogrel with aspirin in acute coronary syndrome (ACS) patients has revealed repeatedly improved vascular outcomes. Present study was aimed to examine the value of CRUSADE bleeding score in predicting bleeding events in patients with acute coronary syndrome (ACS). Material and Methods: Present study was single-center, prospective, observational study, conducted in patients with ST Elevation Myocardial Infarction. The Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the ACC/AHA Guidelines (CRUSADE)6 score was calculated according to patients’ hematocrit, creatinine clearance rate, heart rate, blood pressure, existence of heart failure, diabetes mellitus, and previous vascular diseases. Results: In present study, 102 patients of STEMI were studied. Mean age was 67.54 ± 10.43 years & majority were male (73.53 %). Mean baseline hematocrit was 39.93 ± 5.67 %. Mean creatinine clearance was 78.96 ± 47.88 ml/min. Mean heart rate was 81.6 ± 16.7 bpm. Mean systolic blood pressure was 137.5 ± 26.7 mm Hg. Signs of congestive heart failure (CHF) at presentation were noted in 9 patients (8.82 %). History of prior vascular disease was noted in 8 patients (7.84 %) & diabetes mellites was noted among 31 patients (30.39 %). 4 patients had evidence of major bleeding (3 had intracranial bleeding & 1 had documented retroperitoneal bleeding). Crusade score of >40 (mean score 55.41 ± 13.3) was observed in all cases. Conclusion: In patients with acute coronary syndrome, CRUSADE bleeding score > 40 can be considered as a predictor of bleeding events.

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