Abstract

Aim: To analyse exercise induced ischemia in newly diagnosed asymptomatic diabetic patients. Material and Methodology: This prospective observational study was conducted in the department of medicine from November 2021 to August 2022. Informed consent of all participants was obtained after explaining the purpose of the study. Permission to carry out the study was obtained from the Institutional Ethical Committee. 100 patients of newly diagnosed asymptomatic type 2 diabetes without clinical evidence of coronary artery disease attending Medicine OPD were recruited for the present study. During the exercise test, data about heart rate, blood pressure and ECG changes was obtained at the end of each stage and at any time an abnormality is detected with cardiac monitoring. Angina or significant ST depression (greater than 2 mm) before completing Stage 2 of the Bruce protocol and/or ST depressions that persist for more than 5 minutes into recovery suggest severe ischemia and high risk for coronary events. Results: Only 2% of the subjects had positive TMT. Mean FBS (mg/dl) and PPBS (mg/dl) was found to be higher among TMT positive as compared to TMT negative subjects, though no significant difference was found. Mean HbA1c (%) was 10.02±1.38 and 8.05±1.14 among the TMT positive and negative subjects respectively with statistically significant difference as p<0.05. Conclusion: We concluded that duration of diabetes, triglycerides level, HbA1c level are strong clinical predictors for SMI in patients of Type 2 DM asymptomatic for exercise induced ischemia.

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