Abstract

Reports of nephrotoxicity and neurotoxicity, however, deterred physicians from using the antibiotic, especially with the emergence of other antibiotics (e.g., aminoglycosides) that were less toxic. Between the 1970s and 1990s, Colistin was not used often, and the number of studies analyzing its use and pharmacology was minimal. The study included multidrug resistant Gram negative bacilli isolated from various clinical samples from patients from all the hospitals. Sample size was calculated as 133, rounded off to 150, assuming 1% alpha error, and 15% relative precision, 69% to 95% sensitivity of Colistin among MDR gram negative bacteria. No major or minor errors were noted in isolates of Pseudomonas spp. Acinetobacter spp. showed minor and major errors of 34.8% and 39.1% respectively. Citrobacter spp. showed predominantly minor error – 60% and major error of 30%. E.coli showed minor and major errors of 48.1% and 14.8% respectively. Enterobacter spp. showed minor and major errors of 50% and 33.3% respectively. Klebsiella spp. showed minor and major errors of 46.2% and 35.9% respectively

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