Abstract

Diabetic foot infections (DFIs) are associated with major morbidity, increasing mortality, high costs, increased risk of lower extremity amputation (LEA), and reduced quality of life. The pathophysiology of diabetic foot infections is complex consequences of host-related complications (immunopathy, neuropathy and arteriopathy) and pathogen-related factors (virulence, antibiotic resistance and microbial load). Present study was aimed to microbiological profile of diabetic foot infections at a tertiary care hospital. Material and Methods: Present study was single-center, prospective, observational study, conducted in diabetic patients, previously diagnosed or newly diagnosed as diabetics and presenting with lower extremity infection. Results of the culture and antimicrobial sensitivity testing were documented. Results: In present study, 98 cases of diabetic foot infections were studied, Majority cases were from 51-60 years age group (41.84 %) followed by 41-50 (28.57 %) & 61-70 (19.39 %) years age group. Mean age of study patients was 52.7 ± 11.3 years. Male (68.37 %) outnumbered female cases (31.63 %). Majority patients had polymicrobial flora (55.1 %) as compared to monomicrobial flora (39%). In present study 21.43 % cases had no growth. Among gram positive organisms majority were staphylococcus aureus (29.59 %), Group B Streptococci (9.18%) & Enterococcus faecalis (2.04 %). While among gram negative organisms pseudomonas aeruginosa (16.33 %), klebsiella pneumoniae (9.18 %) & escherichia coli (7.14 %) were most common organisms. Conclusion: Most of specimens were poly microbial infection and predominant bacteria were S. aureus and Pseudomonas sp. All bacterial isolate in our study have sensitivity for Levofloxacin, Pipracillin- Tazobactum, Linezolid, and Meropenem.

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