Abstract

Pre-eclampsia (PE) is a significant public health problem globally, affecting both developed and developing countries and causing maternal and perinatal morbidity and mortality. Early detection and diagnosis of PE is very challenging. To gain insights into the pathophysiology of PE, we conducted a study to know oxidative stress. Method: The study involved 60 subjects in their third trimester of gestation, comprising 30 pre-eclamptic (case) and 30 normotensive pregnancy (control). Samples were collected using inclusion and exclusion criteria from Obstetrics and Gynecology department in and outpatients at Jawahar Lal Nehru medical college and hospital (JNMCH) Aligarh Muslim University (AMU), Aligarh, Uttar Pradesh, India. Serum Malondialdehyde (MDA), was measured in micromoles of Thiobarbituric acid reactive substances (TBARS). Result was analyzed by using appropriate statistical tests and considered significant when p<0.05. Results: The mean (± SD) value of serum malondialdehyde (MDA) in terms of micromoles of TBARS was 0.899 ± 0.287 micromoles/ml in PE, while it was 0.478 ± 0.201 micromoles/ml in controls. This increase in PE was highly significant (P= 0.0001). The result indicated a significantly higher level of serum MDA in pre-eclamptic compared to normotensive. Conclusion: In conclusion, the study sheds light on important factors associated with PE, including oxidative stress. Early identification and management of these risk factors could be critical in decreasing the incidence of PE and its adverse outcomes for both mothers and babies. However, further research is needed to understand these findings.

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