Abstract

Background: Dengue is one of the most important emerging viral diseases of humans in the world afflicting humanity in terms of morbidity and mortality.. All ages and both sexes are susceptible to dengue fever. Present study was aimed to study prevalence of dengue in different age groups and sex distribution at a tertiary hospital. Material and Methods: Present study was prospective, observational study, conducted in patients who were diagnosed as positive for Dengue NS1 antigen or Dengue Ig-M antibodies/ IgG antibodies. Results: The maximum numbers of cases were in the age group of 11-20 years (36.80%), followed by in 21-30 years (21.80%). It was observed that the clinical data diagnosis of DF (77.20%) cases, DHF (18.64%) followed by DSS (4.20%). The mode of presentation in the present study was fever (100%), followed by headache (70.2%), myalgia (63%), arthralgia (48.2%), retro-orbital pain (46%), pain abdomen (21.2%), hepatomegaly (21.6%), rashes (17.4%), petechiae (13.8%), Splenomegaly (13.4%) and CNS manifestations (1.4%). Out of 500 cases (19.69%) showed positivity for NS1 antigen. The observation for individual markers IgG antibody were statistically significant with p-value of 0.001 and significant for IgM antibody with p-value of 0.03. The observations were statistically significant for combined NS1+IgM and NS1+IgM+IgG with a p- value of < 0.01. The maximum numbers of cases were recovered (93.6%), followed by discharged against medical advice or referred (4.6%). The patients expired were 9 (1.8%). The correlation of the clinical spectrum of dengue with died patients was significant with p- value was <0.05. Conclusion: Patients in the study presented commonly with fever, followed by headache, myalgia, arthralgia, retro-orbital pain, rash and petechiae. Clinical findings of the cases included hepatomegaly, Splenomegaly, pleural effusion, ascites and shock.

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