Abstract

Prediabetes is a preclinical stage in the hyperglycemia continuum where subjects are at increased risk of developing diabetes in the near future. The purpose of the present study was to compare MPV in prediabetic and normoglycemic subjects, and to evaluate the relationship between MPV,HbA1c and fasting plasma glucose (FPG) levels in these two groups. Material and Methods: Present study was single-center, case-control study, conducted in 100 individuals, 50 prediabetics and 50 normoglycemics, of age > 18 years, either gender, willing to participate in present study. Results: The mean BMI in controls was 22.6 ± 1.972 and 25.3 ± 3.825 in cases, difference was highly significant (p<0.001). The mean FBS, PPBS and HbA1c in controls were 90.08±10.089, 113.68 ± 9.696, 5.25 ± 0.308 and 111.36 ± 15.398, 156.68 ± 12.099, 6.02 ± 0.222 in cases respectively, difference was highly significant (p<0.001). We observed that MPV in prediabetic subjects was higher than that in normoglycemic subjects. The mean MPV in normoglycemics and prediabetics was 9.24 ± 0.950 and11.62 ± 0.442 respectively, difference was highly significant (p<0.001). We observed a positive correlation between MPV and FPG, PPG, HbA1c levels, not only in the prediabetic but also in the normoglycemic subjects [ FPG (r=0.540), PPG (r=0.748), HbA1c (r=0.815) for prediabetics and FPG (r=0.585), PPG (r=0.809), HbA1c (r=0.817) ]. We studied correlation of MPV with HbA1C values of prediabetic patients (in 2 groups as 5,7-6 % & 6.1-6.4 %), a positive correlation was noted between MPV with HbA1C values of prediabetic patients. Conclusion: Mean platelet volume was found to be increased in prediabetics compared to normoglycemics. In prediabetic and normoglycemic subjects, MPV showed positive correlation with FPG, PPG and HbA1c levels.

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