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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    Study of Role of Red cell indices in distinction between macrocytosis of aplastic and megaloblastic anemia in Patient, attending in SKMCH, Muzaffarpur.


    Dr. Dilip kumar, Dr. Mahesh prasad , Dr. Satyendu sagar , Dr. Manoj kumar
    JCDR. 2023: 92-95

    Abstract

    Megaloblastic anemia and aplastic anemia are the major cause of pancytopenia. Due to the presence of macrocytes, in both magaloblastic anemia and aplastic anemia, peripheral blood smear examination cause difficulty in differentiation between the two in the absence of macro - ovalocytes and hypersegmented neutrophils.The present study measures the role of red cell indices in differentiation between macrocytosis of aplastic anemia and megaloblastic anemia.Material and Method-Hemogram of a total 22 Patients each of biopsy proven megaloblastic anemia and aplastic anemia were included in the study.Result- It was observed that MCV was greater than 94 fl in 09 Patients of aplastic anemia (mean MCV 107.2 fl), and 22Patients of megaloblastic anemia (mean MCV 111.25 fl).Hb, MCV and MCHC were comparable in the two groups. However, mean RDW in megaloblastic anemia (mean 87.2 fl) was significantly higher than those in aplastic anemia (mean 71.6 fl). Conclusion-Red cell distribution width measures to differentiate between the megaloblastic anemia and aplastic anemia.

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