Abstract

Type 2 Diabetes Mellitus is one of the most common metabolic endocrine disorder characterised by hyperglycemia. It is caused by a complex interaction of genetics and environmental factors. In DM , lipid abnormalities, anaemia, alteration of liver and kidney functional indices have been implicated as major risk factors to the progression of Diabetic complications. Ferritin is an index of body iron stores & acts as an iron overload marker. The relationship between iron metabolism and type 2 DM is bidirectional. Iron is a potent pro-oxidant that increases cell oxidative stress causing decreased insulin internalization and actions resulting in hyperinsulinemia and insulin resistance. Serum Ferritin, an acute phase reactant is a marker of iron stores in the body. Increased serum ferritin, reflecting body iron overload, is often associated with measures of insulin resistance, such as elevated blood glucose and insulin levels.

Description