Journal of Cardiovascular Disease Research
Study of Serum Lactate Dehydrogenase in Pregnancy Induced Hypertension
Sangeeta B. Singh, Shikhaa Mahajan, S.P Singh, Farah Deeba Khan, Asha Kumari, Yuthika Agrawal
JCDR. 2023: 2303-2308
Abstract
Hypertensive disorders in pregnancy are one of the common medical complications of pregnancy and contributes significantly to maternal and perinatal morbidity and mortality. Lactate dehydrogenase (LDH) is an enzyme that catalyses the oxidation of L lactate to pyruvate. LDH levels are increased in the scenario of damaged tissues, increased cell leakiness, hemolysis and cellular damage caused by pregnancy induced hypertension and its severity. Objective: To estimate and compare the levels of serum lactate dehydrogenase in pregnancy induced hypertension (PIH) cases and controls. Materials and Methods: A hospital-based case control study was conducted in SHKM GMC Nuh Haryana between August 2021 to July 2022, on 90 cases of PIH (Mild preeclampsia, Severe preeclampsia and Eclampsia) and 90 controls aged 18-45 years females visiting the hospital, following inclusion and exclusion criteria and willing to participate. Samples were collected and analyzed for serum LDH by fully automated analyzer using spectrophotometry. Results: Mean values of serum LDH levels in Eclampsia were (1365.17±275.22 U/L), severe preeclampsia was (791.13±93.96 U/L) and mild preeclampsia were (422.37±72.13 U/L), while in controls it was (193.71±34.12 U/L). On comparing statistically, a significant difference was observed between the groups with p value <0.001. Conclusion: LDH levels can be used to assess the extent of cellular death and thereby the severity of disease so as to prevent progression of preeclampsia to eclampsia
» PDF