Abstract

To study the spectrum of various neurological manifestations among PLHA. To evaluate the association of these neurological manifestations with CD4 count among PLHA. Material and methods: This study will be conducted on PLHA presenting in ART centre, OPD and IPD in the Department of Medicine. It will be a hospital based cross-sectional study. The study will be carried out after approval from Institutional Ethics Committee, Guru Gobind Singh Medical College and Hospital, Faridkot. Written informed consent will be obtained from all the participants. A detailed clinical history and CNS examination for higher mental functions, MMSE, cranial nerve examination, reflexes, motor system and sensory system examination will be carried out. Patients will undergo routine haematological and biochemical investigations including CD4 count, along with other relevant test if required such as cerebro-spinal fluid (CSF) analysis,Computed tomography(CT) Head and Magnetic resonance imaging(MRI) brain, Nerve conduction velocity (NCV).HIV testing is done through ELISA. Results: Mean age(years) of study subjects was 30.2 ± 5.9. Mean value of CD4 count(cells/mm³) of study population was 228.45 ± 167.63. Mean value of CD4 count(cells/mm³) of study population was 228.45 ± 167.63. Headache followed by fever was the most common presentations.TBM was the most common cns manifestation in 33% cases. Mean ± SD of CD4 count(cells/mm³) in patients without cryptococcus was 279.74 ± 169 which was significantly higher as compared to patients with cryptococcus (108.77 ± 82.47).(p value <.0001). Mean ± SD of CD4 count(cells/mm³) in patients with cranial nerve involvement was 300.88 ± 206.22 which was significantly higher as compared to patients without cranial nerve involvement (205.58 ± 147.78).(p value=0.014). Mean ± SD of CD4 count(cells/mm³) in patients with CVA was 311.78 ± 233.12 which was significantly higher as compared to patients without CVA (197.63 ± 124.28).(p value=0.021

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