Abstract

The prevalence of metabolic syndrome in polycystic ovary syndrome has been studied in different populations. Present study was done with an objective to identify women with PCOS at risk of developing the metabolic syndrome and the association of individual metabolic parameters with PCOS. Material and Methods: A prospective observational study was done at a tertiary care hospital in 200 non pregnant women aged 18-35 years diagnosed with PCOS in OPD of department of Obs & Gyne using Rotterdam’s criteria. The study variables included age, menstrual pattern, Blood pressure (SBP/DBP), body mass index (BMI), waist circumference (WC), FG score, PCO pattern on ultrasound, fasting plasma glucose, fasting lipid profile. Metabolic syndrome was diagnosed according to AHA/NHLBI (ATP III 2005) definition. Fisher’s exact test and unpaired t test were applied for statistical analysis. Results: Out of 200 total numbers of confirmed subjects with PCOS, only 46 met the diagnostic criteria for MBS criteria, hence percentage prevalence of metabolic syndrome in PCOS is 23%.Among those who met criteria for Metabolic syndrome, Waist circumference ≥80 cms and serum TGs ≥150mg/dl were the most commonly deranged parameters in all 46 (100%) women followed by HDL≤50mg/dl in 40 (86.9%), FBS ≥110mg/dl 38 (82.60%) and SBP/DBP ≥ 130 / 85 mmHg in 28 (60.8%) women. Acanthosis nigricans were observed 88% of women in PCOS with metabolic syndrome group, which is significantly higher than 62% in PCOS group. Conclusion: Women with PCOS particularly those with increased BMI, WC (≥88cms), USG morphology of PCOS, acanthosis are important risk factors for association of PCOS with Metabolic syndrome in significantly higher numbers and it is important to initiate screening for the same.

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