Abstract

It has been observed that chronic kidney diseases(CKD) are often associated with thyroid dysfunction .Thyroid functional derangements in CKD are linked with excessive mortality from cardiovascular causes and death in CKD patients due to accelerated development of atherosclerosis. Keeping in view the cardiovascular mortality associated with the deranged thyroid profile there is need to understand the relationship between the thyroid and the kidney more thoroughly and verify the accuracy of earlier findings. Aims & Objectives: The study aimed to assess the thyroid profile in patients with kidney disease and to correlate T3 and TSH with S Creatinine and Glomerular filteration rate (GFR) and to finally to study the C Reactive Protein (CRP) positivity in CKD patients with thyroid dysfunction . Methods: The study group comprised of 70 patients with kidney diseases from 30 to 65years from Out Patient and Inpatient Departments of the a tertiary hospital. Results: Out of the 70 patients in the study 38(54.29%) of patients were males and 32 (45.71% ) patients were females. 44 patients (62.8%) had thyroid disorder .30% of patients had Hypothyroidism, 20% had Sub clinical Hypothyroidism and 7.14% had Low T3 syndrome, 4.2% had Low T4 , 1.4% patient had high T4 and 26 patients (37.2%) were euthyroid patients.The prevalence of thyroid dysfunction was higher in the group with GFR <15ml/min(Stage 5) ( statistically insignificantly).Patients with higher TSH and low T3 were more prevalent in patients with lower GFR though statistically significant correlation could not be elicited. CRP positivity in CKD patients with thyroid dysfunction was significantly higher than those without any thyroid dysfunction . Conclusion : Hence, it can be concluded that thyroid disorders are common in patients with chronic kidney diseases and the prevalence of thyroid dysfunction corresponds with severity of CKD.Therefore, it is essential that we screen the patients with CKD for thyroid dysfunction routinely, and manage accordingly in order to avoid excessive cardiac mortality and progression of CKD.

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