Abstract

Normal vaginal flora that is lactobacillus maintains the vaginal PH thus preventing women from day to day infection. Premature membrane rupture puts the mother and fetus at risk for complications such maternal infection, fetal infection, umbilical cord compression, cord prolapse, fetal death, poor Apgar score, pulmonary hypoplasia, preterm delivery, low birth weights, and fetal deformities. Our aim is to study spectrum of vaginal flora in women with premature rupture of membrane and it's association with maternal and perinatal outcome. Methodology: A prospective observational study was conducted in 128 women admitted with premature rupture of membrane in obstetric wards of R D Gardi Medical College, Ujjain; over one year. All pregnant women with gestational age more than 28weeks admitted in obstetrics ward having complaint of leaking per vagina were included in this study. Swab were collected for culture and sensitivity to laboratory. Result: Mean age was 26.28 ±4.12 years, and median age was 27 years. In high vaginal swab cultures, growth was observed in 73 women (57.0%). E.coli was the commonest observed organism ( 22.7%) followed by Staphylococcus aureus (14.1%). Mixed growth was seen in 8.6% women . Maternal outcome was fever (10.9%), UTI (9.4%), puerperal sepsis(3.1%), chorioamnionitis(4.7%) and wound infection(4.7%). Neonatal outcome were NICU admissions , Prematurity, Low Birth Weight and Neonatal Sepsis in 35.6%, 19.2% ,28.8% ,6.8% respectively. Conclusion: In this study we conclude that 57% women had abnormal vaginal flora in pregnant women presenting with PROM and were linked with adverse pregnancy outcome and adverse neonatal outcome. We conclude that microbiologic screening in early pregnancy may aid in the assessment of patient risk for preterm delivery.

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