Abstract

Background: Dengue is the most important arthropod borne viral infection of humans. The increasing number of cases and deaths in these patients due to clinical and hematological complications are rising, thus present study was aimed to study correlation of clinical, hematological & serological findings with disease severity & clinical outcome in confirmed dengue cases at a tertiary hospital. Material and Methods: Present study was single-center, prospective, observational study, conducted in patients diagnosed as positive for Dengue NS1 antigen or Dengue Ig-M antibodies/ IgG antibodies. Results: The maximum numbers of cases were in the age group of 11-20 years (36.80%), followed by in 21-30 years (21.80%). It was observed that the clinical data diagnosis of DF (77.20%) cases, DHF (18.64%) followed by DSS (4.20%). Among the cases the clinical symptoms like Myalgia, Arthralgia, Vomiting, Pain abdomen, Rashes, Shock and tourniquet test was statistically significant.(P<0.05) Out of 500 cases (19.69%) showed positivity for NS1 antigen. The observation for individual markers IgG antibody were statistically significant with p-value of 0.001 and significant for IgM antibody with p-value of 0.03. The observations were statistically significant for combined NS1+IgM and NS1+IgM+IgG with a p- value of < 0.01. The correlation of the clinical spectrum of dengue with thrombocytopenia was highly significant with p- value was <0.01. The maximum numbers of cases were recovered (93.6%), followed by discharged against medical advice or referred (4.6%). The patients expired were 9 (1.8%). The correlation of the clinical spectrum of dengue with died patients was significant with p- value was <0.05. The correlation of the thrombocytopenia with died patients was significant with p- value was <0.05. Conclusion: Pronounced hematological changes are associated with the disease severity and play an important role in recognizing the illness in the early stage.

Description