Abstract

The aim of the study is to observe changes in vital parameters before and after 90-120 minutes of oral melatonin premedication on induction doses of pentothal sodium and propofol. All patients fulfilling the inclusion criteria were given general anaesthesia at our study. Study was carried out on patients of ASA grade 1 and ASA grade 2 category between age group 18 to 60 years, scheduled to undergo elective surgery under General Anaesthesia. Result: The mean SBP 120 minutes after drugs was significantly less in PS + M Group compared to P + M Group, PS Group and P Group. The mean SBP pre induction was not significantly less in P + M Group compared to PS + M Group, P Group and PS Group. We observed that the mean DBP preinduction was not significantly more on PS group compared to P Group, P + M Group and PS + M Group and the mean DBP 120 minutes after drugs was significantly more in PS Group compared to P Group, P + M Group and PS + M Group and the mean DBP pre induction was significantly lower in PS + M Group compared to P + M Group, P Group and PS Group. Conclusion: We concluded that statistically significant effect was found when oral melatonin used as premedication was given before induction doses of propofol and Pentothal sodium and changes in the vital parameters were observed 120 minutes after administration of study drug.

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