Abstract

The aim of the present study was to assess the histopathological features of different types of hyperplasia of prostate, prostatic intraepithelial neoplasia and prostatic carcinoma in transurethral resection of prostate (TURP) samples and needle core biopsies. Methods: This prospective study was undertaken at the Akash Institute of Medical Sciences from 2019 to 2021. 120 patients were included in the study. Results: Most of the cases in the present study were in the range of 61 to 70 years of age (60 cases) followed by 71 to 80 years (37 cases) and 51 to 60 years (19 cases) respectively at the time of biopsy for symptomatic obstructive uropathy. Out of the total 120 cases studied, 109 cases (90.8%) were non-neoplastic and 11 cases (9.2%) harbored neoplasms. The most common clinical symptoms in non-neoplastic lesions are as follows: frequency, retention, hesitancy, urgency dysuria. On digital examination, of 109 non-neoplastic cases, 105 were firm whereas 4 cases were hard in consistency. Out of 11 neoplastic cases, all 11 cases were hard in consistency. On comparing neoplastic and non- neoplastic cases, hard nodule was significantly associated with neoplasms. Serum Prostate Specific Antigen levels were assayed using immunoassay and were available for 80 cases (67.5%). Among these 80 cases, PSA values in 04 (5%) were within normal range (up to 4 ng/dl). In the 109 cases of benign hyperplasia of prostate, varying proportions of glands and stroma was noted, from which, cases showing a characteristic pattern or predominance was identified. Of the 109 cases of benign prostatic hyperplasia, Corpora amylacea were seen in 30.2% of cases. The other findings were basal cell hyperplasia (3.7%) and squamous cell metaplasia (0.9%). Other stromal findings encountered were ectatic thick-walled blood vessels and stromal edema. Conclusion: TURP plays a significant role in the diagnosis of prostatic lesions. The benign lesions are more common the malignant ones. The modified Gleason score is applied for prostatic cancer, which is simple and accurate to grade these malignancies.

Description