ISSN 0975-3583
 

Journal of Cardiovascular Disease Research



    THE ANALYSIS OF THE SUB-FRACTIONS OF HIGH-DENSITY LIPOPROTEIN (HDL) CHOLESTEROL IN THE GROUP WITH AND WITHOUT DIABETES


    Koppukonda Ravi Babu, Bonagiri Shanthi, Aparna Varma Bhongir
    JCDR. 2023: 3591-3595

    Abstract

    It is HDL2 that is primarily responsible for mediating the protective effect of HDL against CAD. Both coronary heart disease and type 2 diabetes mellitus have been linked to elevated total cholesterol levels, as well as elevated triglyceride and lower HDL cholesterol levels. a comparison of HDL subfractions in diabetic and non-diabetic populations is the focus of this research. Methods: Case-control research blood from 33 healthy subjects without diabetes and 28 people with diabetes who have just been detected. Sample was taken from Department of Biochemistry, Mediciti Institute of Medical Science, Hyderabad, Telangana, India between January 2015 to June 2015. The homogeneity of HDL-C was measured using a colorimetric enzymatic test. HDL3-C was measured using the simple precipitation method1 by adding Heparin/Mn/DS reagent. The statistical significance of the differences in means was determined using unpaired t-tests. Results: HDL 2 levels were significantly higher in non-diabetic group compared to the diabetic group, there is no significant difference between Diabetic and Non- Diabetic groups in HDL 3 levels. Total cholesterol, LDL, and Triglycerides are significantly higher in Diabetics compared to non-Diabetic group. Conclusion: The research demonstrated that the method for calculating HDL-C fractions was straightforward and economical.

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    Volume & Issue

    Volume 14 Issue 1

    Keywords