Abstract

CKD's relationship to incident heart failure is uncertain. In 10,190 male patients, we examined CKD with incident nonfatal heart failure and cardiovascular (CVD) mortality (mean age, 65years). Kidney function was measured by estimated glomerular filtration rate (eGFR) using the Modification of Diet in Renal Disease equation in clinically relevant categories of <60 and 0 ml/min/1.73 m2 (referent); and <45, 45 to 60, 60 to 90, and 90+. (referent). In multivariable models, males with eGFR<60ml/min/1.73 m2 had a 2-fold incidence of heart failure (95% CI, 1.62-2.56, p<0.0001) compared to reference group. Compared to the reference group, the hazard ratio [HR] for heart failure in eGFR categories of 60-90, 45-60, and <45ml/min/1.73m2 was 1.25 (0.99-1.61), 2.58 (1.95-3.50), and 1.55 (0.95- 2.81). in the subgroup of non-diabetics and normotensive people at baseline (n=7545), males with eGFR<60 ml/min/1.73 m2 had 2.2-fold risk of heart failure (95% CI 1.69-2.91). Compared to reference group, those with eGFR 45-60 and <45 ml/min/1.73 m2 had >2.5-fold increased risk of heart failure or CVD mortality.

Description