Abstract

Triple negative breast carcinomas (TNBC) are a very aggressive type of breast carcinoma. In this study the expression of p53 in triple negative breast carcinoma cases was observed and correlated with age, tumor size, grade, lymph node status and other parameters. Methods: In the present study 52 cases of histologically and immunohistochemically proven Triple negative breast cancer cases were taken and subjected to IHC for p53 expression. Result: A total of 52 female patients with TNBC were taken for the study. The age of the patients varied from 30 - 81 years old and the maximum number of cases was seen in the age group of 41- 50 years old. Left side was involved in 57.7% of the cases. The upper outer quadrant was most involved in 63.5% of all cases. The tumor size varied from 1 cm to 8 cm. Maximum number of cases presented with a size variation of 2 - 5 cm (78.8%cases). Of all these cases, 92.3% were of IDC- NOS type. In our study 59.6% cases were of grades III and 34.6% were of grade II while 5.8% were not assigned any grade. There were no cases of grade I. Lympho- vascular invasion was seen in 82.7% cases. As the grade of the tumor increased, LVI also increased. This correlation was statistically significant (p value 0.042). Lymph nodes were recovered in 94.2% cases. Lymph node metastasis was seen more commonly in premenopausal age groups (<50) as compared to postmenopausal age groups (>50). This correlation was statistically significant (p value 0.025). Metastatic carcinomatous Lymph node deposits were present in 55.1% cases. No correlation was found when LN status was correlated with tumor size, and perineural invasion. The expression of p53 was noted in 61.5% cases. The p53 expression was most seen in the age group of 41-50 years. A direct correlation was found between p53 expression and LVI. This correlation was statistically significant (0.011). No statistically significant correlation was noted while correlating p53 expression, its intensity and cumulative score with age, tumor size, tumor grade, and perineural invasion. Conclusion: In the present study we established that cases with p53 overexpression were mostly high grave and had a higher potential for metastasis.Thus p53 helps to provide better prognostic evaluation and can become a novel antigen for targeted therapy.

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