Abstract

Analytical Observational study. Purpose: To evaluate the effect of Anti-hypertensives on Systolic perfusion pressure (SPP), Diastolic perfusion pressure (DPP),Ocular perfusion pressure (OPP) and their association with progression of Primary Open Angle Glaucoma(POAG). Materials And Methods: Based on ICD-10,patientson Anti-hypertensives were divided into Early(n=15), Moderate(n=15) and Advanced(n=15) glaucoma and their SPP, DPP, OPP were assessed. Anova test was used to see the statistical significance among groups. P value <0.05 was considered significant. Results: DPP, SPP and OPP were significantly lower in Advanced stages of glaucoma when compared to Early and Moderate stages. Conclusion: Anti-hypertensives lowering the Perfusion pressures will have a detrimental effect on already compromised optic nerve head in Glaucoma patients. High SBP leads to decrease in vessel diameter whereas patients with low DPP will have low OPP. Bed time Anti-hypertensives exaggerate the Nocturnal dipping of BP further aggravating the disease process. Hence it is better to avoid night dosage in patients with very low OPPs.

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