Abstract

Pregabalin is a gabapentinoid which has been shown to possess analgesic and anxiolytic properties. The present study was conducted to assess the effect of pregabalin premedication on preoperative anxiety and post operative pain scores and opioid consumption in patients operated for lumbar laminectomy and discectomy. Method: A total of 75 patients were randomised equally into three groups- Group A: received placebo (B-complex); Group B: received pregabalin 150mg and group C: received pregabalin 300mg. Results:TheVAS anxiety score was significantly lower in Group B (17.96±5.08) and Group C (13.40±2.65) compared to Group A (45.08±10.12), (p<0.05).The HR, SBP, DBP and MAP levels in Group A and B were significantly higher compared to Group C from 30 mins till150 mins post induction, (p<0.05). The mean intra-operative (210.40±3.47ml vs. 150.44±3.74ml vs.167.76±3.97ml) and post-operative fentanyl consumption (339.12±3.36 ml vs. 212.16±3.59 ml vs. 189.64±3.78 ml) was significantly higher in GroupA compared to Group B and C. The mean VAS scores for pain at rest and in pain on movement in first 5hrs was significantly higher in Group A compared to Group B and C, (p<0.05). Conclusion: Pregabalin in both the doses of 150 and 300mg given prior to surgery can significantly reduce preoperative anxiety and intraoperative requirement of fentanyl compared to placebo. Pregabalin 300mg significantly decreased postoperative pain VAS scores at rest and on movement during the first 5 h after surgery. Therefore, the single use of pregabalin in doses between 150 and 300 mg is both safe and effective for reducing preoperative anxiety with a favourable postoperative analgesic profile.

Description