Abstract

According to recent research, decreased renal function and cardiovascular disease are significantly linked to elevated serum levels of uric acid and hs-CRP. In order to identify early renal function deterioration before the start of proteinuria and cardiovascular risk in type 1 diabetic patients, this study will examine the roles of uric acid and hs-CRP. Method: In the cross-sectional study, a total of 140 type 1 diabetic individuals (70 normoalbuminuric and 70 microalbumin uric) were enrolled. Enzymatic colorimetric method and ELISA method were each used to quantify uric acid and hs-CRP, respectively. Blood pressure, body mass index, HbA1c, fasting plasma glucose, plasma lipid profile, serum creatinine, and urine albumin creatinine ratio were also evaluated as metabolic markers. The CKD-EPI equation was used to compute the estimated glomerular filtration rate. Result: Mean uric acid levels were 3.92+/-1.59 and 4.99+/-2.48mg/dL, respectively, for normoalbuminuria and microalbuminuria (p-0.004). Mean hs-CRP levels were 1.93+/-2.14mg/L in normoalbuminuria and 4.47+/-3.05mg/L in microalbuminuria, respectively (p <0.001). Urinary albumin to creatinine ratios were 15.74+/-8.88 in normoalbuminuria and 129.98+/-85.25 in microalbuminuria (both p<0.001). The mean GFR in individuals with normoalbuminuria was 112.45+/-20.30ml/min, whereas it was 100.25+/-27.12ml/min in individuals with microalbuminuria (p-0.02). A greater than 90 ml/min eGFR was present in 55.6% of normoalbuminurics and 47.5% of microalbuminurics. The eGFR was less than 90 ml/min in 36.8% of normal albuminurics and 67.6% of microalbuminurics. Lower GFR was strongly and independently linked with both elevated blood uric acid and elevated urine albumin creatinine ratio. Uric acid and hs-CRP correlated positively (p-0.04 and p0.001, respectively), whereas uric acid and eGFR correlated negatively. Conclusion: When blood uric acid levels were in the upper normal range and hs-CRP levels were elevated, renal function was decreased in patients with type 1 diabetes. As a result, in the clinical setting in India, where the detection rate is lower and the repercussions are more frequent, it can be used as markers for identifying cardiovascular risk and early renal function deterioration in patients with type 1 diabetes

Description