Abstract

As we are aware that chronic liver disease frequently associated with haematological abnormalities which presents Anaemia of diverse etiology occurs in about 75% of patients and also this condition may be exacerbated by deficiency of folic acid and/or vitamin B12 that can occur secondary to inadequate dietary intake or malabsorption. So In this study we want to evaluate chronic liver disease patients having anaemia without overt bleeding in the past 3 months to know the severity and type of anaemia in these patients so as to enable us better management and decrease associated morbidity and mortality. Research Question: .What is the scenario of anaemia in the spectrum of chronic liver disease in our setup? The setting of the study was at department of Gastroenterology, Government General Hospital, Guntur Medical College, Guntur, Andhra Pradesh. A one year observational study was conducted during the period from April 2022 to May 2023 on about 100 chronic liver disease patients having anaemia whose Hb levels <10 g/dl without overt bleeding in the past 3 months admitted during the above period in the department of Gastroenterology by studying their socio-demographic profiles, type of chronic liver disease and anaemia with related laboratory investigations etc. Results: It was observed that in ALC the most common anaemia is folic acid deficiency (39.7%) followed by Iron deficiency (37.2%), in HBV most common anaemia was Iron deficiency (54.5%) followed by Folic acid deficiency (36.4%), in HCV both Iron and Folic acid deficiency were equally distributed (42.9%) and in NAFLD Iron and B12 deficiency were equally distributed (25%). Regarding severity, about 14% were severely anaemic flowed by 63% moderately anaemic and 23% were mild anaemic as noticed. In this study among the ALC cases maximum 35.9% were belong to the age group 41-50 years followed by 45.5% belong to 51-60 among HBV,42.9% belong to 41-50 years among HCV and about 50% of cases belong to 41-50 years among NAFLD. Totally it was observed that the majority age group suffering from chronic liver disease was between 41 -60 years. Mean age of study subjects was 46.7 years. And the lowest mean values of serum iron (29.29mcg/dl) and folic acid (4.59ng/ml) was observed among HCV cases and serum vit-B12 (221.3pg/ml) seen in ALC cases in this study.

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