Abstract

Anti Mullerian Hormone (AMH) is a new diagnostic biomarker of ovarian reserve and is indicative of infertility. Present study is an attempt to measure serum AMH and to compare it with different parameters like age, BMI, history of smoking in women with infertility Methodology: This cross-sectional observational study was conducted in department of Biochemistry Darbhanga Medical College Laheriasaria. 60 women diagnosed with infertility in the age group of 21 to 55 years were consecutively selected from department of Obstetrics and Gynaecology. 60 age matched healthy controls were also taken from same department. Subjects were divided into two groups Study Group (Subjects with infertility) and Control Group (Healthy age matched controls). 2 ml venous blood was collected from antecubital vein of all subjects. Serum AMH was measured using Ultra-sensitive AMH/MIS ELISA AL-105i. BMI was calculated using Adolphe Quetlet method. History of smoking was taken while interviewing the patient. Sociodemographic data were recorded or sociodemographic performa-1. All observations were recorded and relation between different parameters was investigated using appropriate statistics. Results: Serum AMH was lower in study group as compared to control group (p=0.001). Levels of AMH decreased with advancing age in both control and study group. AMH decreased as BMI increased in both the groups. Smokers in both groups had lower AMH than non-smokers. Conclusion: AMH is a biomarker of infertility as it is low among women with infertility as compared to healthy women. Advancing age, weight gain and smoking decrease its levels.

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