Abstract

Permanent pacing can often lead to the deterioration of ventricular function with time, resulting in a gradual decline in cardiac performance. This study aimed to evaluate the impact of paced QRS duration (pQRSd) on left ventricle (LV) function in patients with single chamber right ventricular apex pacing. Methods: This prospective, single-center study was conducted at a tertiary care center in India between November 2017 and January 2019. A total of 135 patients having atrioventricular disease received single chamber pacemaker implantation were enrolled. These patients were stratified in two groups, i.e., those with baseline pQRSd <150 ms those with baseline pQRSd ≥150 ms. The study outcomes were heart failure, changes in LV ejection fraction (LVEF), and alterations in LV dimensions. Results: The mean age of patients was 65.92 ± 9.64 years and 59 (60.2%) were male. After one year of follow-up, the reduction in LVEF was significantly higher in patients with baseline pQRSd ≥150 ms as compared to patients with pQRSd <150 ms (P = 0.01). The elevation in LV end-diastolic diameter (LVEDD) was significantly higher patients with pQRSd ≥150 ms than in patients with pQRSd <150 (P = 0.01). Moreover, increase in LV end-systolic diameter (LVESD) was numerically higher in patients with pQRSd <150 ms as compared to patients with pQRSd ≥150 ms (P = 0.13). Conclusions: Prolonged pQRSd has a negative impact on cardiac function, causing a decrease in LVEF and an increase in both LVEDD and LVESD, particularly in patients with baseline pQRSd ≥150 ms

Description

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