ISSN 0975-3583
 

Journal of Cardiovascular Disease Research



    To assess advantages and limitations of peripheral blood smear and bone marrow examination.


    Dr. Geeta Devi, Dr. Hemlata Bamoriya, Dr. Abha Patel, Mariya Khatoon Ansari
    JCDR. 2023: 996-998

    Abstract

    The aim of the study is to assess advantages and limitations of peripheral blood smear and bone marrow examination. The bone marrow aspirate of about 0.2 ml is discharged into the elevated part of the slide. Sufficient quantity was used to make direct smears. The slides were stained with Romanowsky stain (Leishman stain) and observed for the quality, fragments, stain, readability and results will be compared with peripheral blood smear. Result: In aspirate smears 16.7% cases had cellularity <50%, 33.3% in 50-75% and 50.0% 75-95%, no case in the 95-100% cellularity. Majority of cases showed increased M:E ratio. 71 % cases fell in the range of 15:1 - 45:1. Storage (pseudo gaucher) histiocytes were present in 3 cases. Mild to marked reticulin fibrosis was seen in 5 cases. Conclusion: Peripheral smear of ITP showed thrombocytopenia with few giant cells. RBCs were microcytic hypochromic. Bone marrow aspirate showed marked megakaryocytic hyperplasia with non-functioning megakaryocytes demonstrating smooth cytoplasmic borders. Peripheral smear gave only the rough idea of the diagnosis in cases of Megaloblastic anemia. Bone marrow aspirate was the most helpful in making the diagnosis. Morphology of megaloblasts was best appreciated in bone marrow aspirate. Bone marrow gave better idea of cellularity.

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    Volume & Issue

    Volume 14 Issue 5

    Keywords

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