Abstract

Introduction: Acne vulgaris causes chronic inflammation in the pilosebaceous units. This is a common dermatological problem that often begins at puberty and last throughout adolescence, affecting both male and female teenagers equally. The objective of this study is to assess the efficacy of oral clindamycin in comparison to doxycyclin for the treatment of moderate to severe acne vulgaris. Oral clindamycin is a safer alternative to doxycyclin for treating moderate to severe acne vulgaris. Material and Methods: This study was designed as a prospective, randomized controlled trial with single-blind methodology. The Outpatient Section of the Department of Pharmacology is located at the Madha Medical College and Research Institute, Chennai, Tamil Nadu, India. The study was conducted from November 2017 to October 2018. Results: In a few of instances, Nausea, Vomiting, and Diarrhoea were of little clinical significance and spontaneously resolved. The patients revealed the incidence of these effects only when specifically asked about their presence. Had the symptoms of diarrhoea and abdominal pain been severe, persons would have undoubtedly informed the investigator. Nevertheless, there were no reports of anyone encountering such symptoms. And all of them continued to take the drug without stopping. It is crucial to note that if Nausea and Vomiting were a result of Pseudomembranous enterocolitis, the symptoms would have exacerbated with ongoing intake. Conclusion: The study suggests the use of oral Clindamycin at modest dosages as a treatment for acne vulgaris. Subsequent trials have the potential to integrate Clindamycin with other topical medications such as Tretinoin and Adapalene, which operate in distinct ways.

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