Abstract

The female reproductive tract is controlled by complex interaction between steroid hormones, gonadotrophins and hypothalamic-pituitary-ovarian axis. A disruption in any of these processes can result in menstrual disturbances. The present study was conducted with an aim to test the hypothesis that subtle endocrinal abnormalities detected by intensive hormone evaluation are associated with menstrual disturbances. Aim & Objective: To compare Prolactin levels in patients with menstrual disturbances with normal healthy fertile females. Methods: The present study was conducted in the Department of Biochemistry. A total of 100 patients reporting to the OPD of Obstetrics and Gynaecology, were studied. Out of 100 patients, 50 patients were with a history of menstrual disturbances, 50 patients of reproductive age group with normal menstrual cycle and with proven fertility were taken as control. Routine investigations were carried out in all the patients. The Prolactin ELISA kit was used for quantitative measurement of prolactin in human serum or plasma. Serial samples were taken for estimation of prolactin. 2 samples were taken on Day 3 of cycle on two consecutive cycles. The serum plasma prolactin reference values used were: Follicular phase upto 22 ng/ml. Result & Conclusion: Considering together, our findings support the hypothesis that women with menstrual disturbances have subtle disturbances in the hypothalamic-pituitary-ovarian axis compared with their fertile counterparts and high prolactin levels play a significant role in the etiology of menstrual disturbances

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