Abstract

This randomised, prospective study's objective is to examine how sevoflurane affects cognitive function and recovery in patients following elective laparoscopic cholecystectomy under general anaesthesia when administered in low flow and medium flow anaesthesia, Eye opening time, Spontaneous breathing time, Concentration of sevoflurane, Cognitive function, Recovery time. Methods: The study received permission from the institutional ethical committee. The patients taking part in the trial provided written informed consent, which was secured. 60 patients between the ages of 25 and 60 who had ASA grades 1 and 2 underwent elective laparoscopic cholecystectomy procedures. From February 2017 to October 2018, this study was carried out at Konaseema Institute of Medical Sciences and Research Foundation in Amalapuram. Results: The MMSE baseline and post-operative scores, the VAS score, the RAMSAY sedation score at 1hr, 3hr, 6hr, and 24hr, and the recovery time at emergence were the parameters tracked. During surgery, the hemodynamic variables ETCO2 and FIO2 were tracked. The threshold for defining postoperative cognitive deterioration was a decrease in MMSE score of more than 2 from baseline. We discovered that the recovery times for the two groups, low flow and medium flow groups, did not significantly differ. The post-operative VAS and Ramsay sedation scores did not significantly differ between the two groups. At one hour following surgery, there was cognitive deterioration in 4 people in the low flow group and 3 people in the medium flow group. Not statistically significant, this. Additionally, there was no change between the two groups' intraoperative hemodynamics. Conclusion: Therefore, we infer that the post-operative cognitive function and recovery of patients undergoing laparoscopic cholecystectomy under sevoflurane anaesthesia are affected by the fresh gas.

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