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Journal of Cardiovascular Disease Research

2021, Vol: 8, Issue: 8
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    To compare the safety of Low-dose Isotretinoin with High dose Isotretinoin in patients with moderate and severe acne


    Dr. Shivansh Kanchan Dr. Pooja Sharma Dr. Aradhana Parmar Dr. Kush Patel Dr. Sankalp Khetan Dr. VK Dey Dr. Animesh Saxena Dr. Anuradha Modi Gupta
    JCDR. 2023: 2471-2475

    Abstract

    The aim of the study is to compare the efficacy of isotretinoin at low dose (0.20 to 0.45mg/kg) vs high dose (0.50 to 0.75mg/kg) at 4, 8, 12 and 16 weeks. In this prospective, comparable study, 100 patients having moderate to severe acne vulgaris were selected after taking an informed written consent using purposive sampling technique. The patients’ records were studied to compile the diagnostic and clinical data including age, sex, site of acne, duration and severity of acne, indications for isotretinoin therapy. Result: 29 cases with nodulocystic acne had high dose of isotretinoin, 10 cases with low dose isotretinoin were resistant to treatment. 10 cases of relapse had high dose treatment. 11 cases and 10 cases had resistance to treatment. significant association was found. 3 cases with high dose of isotretinoin treatment had previous treatment on isotretinoin. While 4 cases with low dose isotretinoin treatment had previous treatment of isotretinoin. Conclusion: In this prospective, comparable study, 100 patients having moderate to severe acne vulgaris were selected after taking an informed written consent using purposive sampling technique. The patients’ records were studied to compile the diagnostic and clinical data including age, sex, site of acne, duration and severity of acne, indications for isotretinoin therapy.

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    Volume 14 Issue 8

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