Abstract

The neonates' vitamin D levels need to be adequately sufficient. This is of the utmost importance. The immunomodulatory effects of vitamin D on immunological function are well established. It was hypothesized that it could play a part in the proper operation of the innate immune system by generating antimicrobial peptides in epithelial cells, neutrophils, and macrophages. This would be an important step in protecting the body against pathogens. Aims and Objective: To determine the correlation of 25-OH Vitamin D levels between newborns with their mothers in case of sepsis. Materials and methods: All infants presenting with symptoms and test evidence consistent with early onset sepsis in the first 72 hours of life were considered cases. All newborns less than 72 hours old who remained in the post natal unit with their mothers and showed no evidence of clinical/laboratory infection were included as controls. There were a total of 110 moms and their newborns analysed in this study: 55 in the case group and 55 in the control group. Results: In Group 1, 83.33% newborns have deficiency level, whereas only 12.5 % have insufficient level while only 4.1% newborns have sufficient levels . while in group 2 (92.85%) newborns had deficiency, (7.1%) has insufficient levels while in Group 3 , 47% newborns have deficiency level and only (4.1%) had sufficient levels of 25-OH Vitamin D levels born to a mother with deficient 25-OH Vitamin D levels. This observation is statistically Significant (p-0.010) Conclusion: According to the findings of this research, a very high incidence of hypovitaminosis D was found among pregnant women, and a strong association existed between the 25(OH) D levels of pregnant women and their unborn children

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