Abstract

Aim: The aim of the present study was to determine the prevalence of celiac disease in a group of first-degree relatives of our patients with celiac disease. Materials and methods: The present study included first-degree relatives of 100 subjects being studied with a diagnosis of celiac disease at Hindu Rao Hospital, Delhi. Parents and siblings of these subjects were invited to celiac disease clinic via telephone to participate in the study. Informed written consent in local language was taken from parents of these children willing to participate in the study and they were explained about the purpose of study. The study has been approved by the ethical and scientific committee of the Hindu Rao Hospital, Delhi. Results: There were 48% males and 52% females. Majority of the subjects belonged to 31-40 years of age. Out of 100, 10% were TTG +ve. The prevalence of TTG Ab positive association was highly significant. TTG was raised up to less than 5 times in 2 subjects of FDR TTG positive group whereas it was 6 subjects in index cases. The value is raised >5 times in 8 subjects of the FDR TTG+VE group and 43 subjects of the index cases. TTG was normal in 1 subject of the index cases. The association was statistically significant (p=<0.001).

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