Abstract

To evaluate and compare hemodynamic parameters including heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR) or spo2 with epidural magnesium sulfate, dexmedetomidine and normal saline during postoperative period. To compare the duration of postoperative analgesia with epidural magnesium sulphate, dexmedetomidine and normal saline. To compare the incidence of postoperative complications including nausea, vomiting, respiratory depression, pruritus, hypotension, bradycardia and sedation. Material and Methods: This was a prospective randomized study that was conducted in the Department of Anaesthesia, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India, during the period of June 2022 to November 2022. The study was approved by the hospital ethics committee. Results: For numerous surgical procedures, regional anesthesia has consistently been linked to favorable results in more than 95% of patients. The importance of it has been acknowledged by both surgeons and anesthesiologists. As a result, the use of localized methods such spinal, epidural, peripheral nerve, plexus, and field blocks is rapidly increasing. As a result, regional anesthesia treatments have become an essential component of an anesthesiologist's current clinical practice. Conclusion: According to the results of the current investigation, magnesium sulfate 50 mg/ml given epidurally in combination with 0.125% bupivacaine creates a synergistic effect that results in an extended period of post-operative analgesia with stable hemodynamic parameters

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