Abstract

People with chronic kidney disease suffer from accelerated atherosclerosis and are more likely to develop cardiovascular disease than the general population. Patients afflicted with chronic kidney disease and cardiovascular disease tend to have significantly worse prognoses than those suffering only from the later. Objective: to study the association of lipoprotien-(a) with left ventricular hypertrophy in patients of chronic kidney disease on hemodialysis. Material and Methods: The present study was conducted in postgraduate department of medicine, S.N. Medical College and Hospital, Agra. Total 82 patients were evaluated and after evaluation on inclusion and exclusion criteria, total 60 patients were included in the study. Out of which two groups were made of 30 – 30 patients. 30 patients of chronic kidney disease were not on dialysis and 30 patients of chronic kidney disease who were on the maintenance dialysis. Results: The hypertrophy was more in hemodialysis group. When compared statistically LVH (echo and ECG findings) showed p<0.05 at 3 month and 6 month which advocated that increase in LVH was significant in hemodialysis group. When Lp(a) value was compared with LVH (Echo and ECG findings) in hemodialysis subjects a positive correlation was established. When compared statistically p was <0.0001, which was extremely significant at 3month and 6 month, which demonstrated that increasing lipoprotein(a) level had a positive correlation with increasing left ventricular hypertrophy. Conclusion: The increased Lp (a) level causes the LVH. So LVH is more in CKD patients on hemodialysis.

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