Abstract

PONV continues to rank as most undesirable surgical outcome despite of multiple advances in recent years with use of nonpharmacological and pharmacological strategies to reduce its incidence to certain extent. Since the inception of general anaesthesia(GA), To assess safety of IV Palonosetron compared to IV ondansetron in relation to adverse effects in post surgical patients undergoing GA .Methods and results: 116 out of 129 patients were recruited for the study based upon inclusion and exclusion criteria and routine investigations and grouped into A and B. palonosetron and ondansertron given to groups and safty and efficacy assessed. In the above table it was observed that mean age among Group A and Group B were 33.93± 10.32 and 34.86 ± 11.43 years respectively Conclusion: Palonosetron was more efficacious than ondansetron in controlling PONV in a post-surgical patients undergoing general anaesthesia.In addition, palonosetron was also effective in reducing PONV in first 24 hours of post-operative period. Overall satisfaction was high in palonosetron receivers than patients whom ondansetron was given.Palonosetron was found equally safe as Ondansetron.

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