Abstract

Sepsis is a major public health issue. Accurately identifying the origin of sepsis in patients is frequently impossible. There is a need for a reliable and accurate biochemical marker to support or rule out bacterial illness. The study's goals were to determine the diagnostic usefulness of serum procalcitonin in Sepsis patients. To see if procalcitonin levels affect the prognosis of Sepsis patients. Materials & Methods: From February, 2022 to January, 2023, conducted at Department of General Medicine, Katuri Medical College and Hospital, Guntur, Andhra Pradesh, India, our tertiary care center conducted a prospective observational research. The study comprised a total of 50 patients. All patients over the age of 18 who presented to our hospital with acute Sepsis during the study period were included in the study sample. The study excluded patients with heart illness, recent surgery, trauma, or malignancies. Results: Procalcitonin was found in 78% of the participants and was statistically significant between groups. The difference in mean procalcitonin levels between sepsis, severe sepsis, and septic shock was statistically significant. A statistically significant difference in mean procalcitonin levels between patients who died and those who survived was 43.78ng/mL versus 6.22ng/mL. The most common cause of sepsis was a respiratory tract infection. Conclusion: Serum Procalcitonin appears to be a helpful diagnostic sign of sepsis as well as a marker of sepsis severity. It was also discovered to be a valuable marker in predicting the fate of sepsis patients.

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