Abstract

The occurrence of repeated pregnancy loss is a matter of significant concern for both the couple experiencing it and the medical professional providing treatment. In this study, we conducted an assessment of the periconceptional correlation between the combination of hyperhomocysteinemia, hypothyroidism, and impaired carbohydrate metabolism and recurrent pregnancy loss. Material and Methods: A descriptive, prospective observational study was conducted between January 2022 to January 2023 to investigate a cohort of 590 consecutive pregnancies with two or more abortions, specifically from our Infertility clinic. All pregnant women underwent routine blood tests, examinations, and imaging procedures in accordance with the hospital's regulations. The study encompassed an examination of all patients in relation to the triad of hypothyroidism, hyperhomocysteinemia, and poor glucose metabolism. Results: The prevalence of recurrent pregnancy loss was determined to be 5.65%. The majority of women surveyed reported having undergone two prior abortions. The majority of women experienced normal conception. The majority of women had a body mass index below 25. The study findings indicated that approximately 60 to 65% of women exhibited the presence of two variables. A total of 56% of female participants indicated the presence of the trio. Approximately 7% of the patient population experienced a subsequent abortion during the second trimester, with 66.6% of these cases exhibiting the presence of the triad relationship. Conclusion: Investigation of these three variables in individuals diagnosed with recurrent pregnancy loss would facilitate prompt identification, ongoing monitoring, and vigilant observation, hence contributing to the prevention of obstetric problems. Implementing a straightforward nutritional intervention could potentially lead to improved maternal and fetal programming as well as effective risk management

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