Abstract

Background & Methods: The aim of the study is to study the antiemetic effect of Ondansetron, Ramosetron and Palonosetron. Detailed history of patients complaints were noted. General and systemic examination of cardiovascular and respiratory system were done. Basic investigations like blood haemoglobin, total count and differential count, blood sugar estimation, blood urea and serum creatinine. Other investigations included E.C.G. and Chest X-ray . Results: Incidence of emetic episodes in group I at extubation is 5, 0-4 hrs is 5, 4-8 hrs is 3, 8-12 hrs is 2, 12-16 hrs is 1, 16-20 hrs is 1 and 20-24 hrs is 1. Incidence of emetic episodes in group II at extubation is 3, 0-4 hrs is 3, 4-8 hrs is 3, 8-12 hrs is 2, 12-16 hrs is 0, 16-20 hrs is 1 and 20-24 hrs is 0. Conclusion: Ondansetron in dose of 0.1 mg/kg i.v given just before induction of anaesthesia, the incidence of post-operative nausea and vomiting was found to be 60%. The antiemetic effect of against Ondansetron is significant. No significant side effect has been found in the present study with use of these drugs except headache which is found more in Ondansetron group.

Description