Abstract

To study the effect of high level of the Hormone Cortisol In Cognitive Impairment In Parkinson's Disease. Methods: This study was done in the department of medicine after taking the ethical permission from the institute. We studied the level of morning plasma cortisol in 50 patients with Vascular Parkinsonism (VP). The relationship between increased morning plasma cortisol and cognitive impairment was determined. The results of the study were statistically analyzed. Cortisol was determined in all blood samples of patients of the category. A (study category) and category B( Control category ). The control category consisted of 50 volunteers. Results: Male duration was greatest in 4-8 years with 13(41.94 percent), followed by 0-4 years with 10(32.25 percent) and more than 8 years with 8(25.81 percent). In women, the length is highest between 0 and 4 years (57.89%), followed by 4-8 years and more than 8 years (5(26.32%) and 3(15.79%), respectively. The normal levels of cortisol were seen in 17 patients (34%), substantial increases in cortisol were observed in 27 patients (54%), and cortisol elevations were reported in 6 individuals (12 percent ). The relationship between the value of cortisol and the assessment of cognitive impairment was determined. In the main category, a statistically significant moderate inverse correlation was determined between plasma cortisol level and cognitive impairment in VP. When studying cortisol levels in VP, its significant increase is noted than in the control (p <0.05). Conclusion: Increased cortisol levels in Parkinson's disease and findings in aged people may have a crucial role in cognitive impairment and over the course of the illness, affecting the efficacy of VP treatment.

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