Abstract

More than 50 years after the advent of effective therapy, Tuberculosis (TB) remains one of the leading causes of adult deaths in the world, disproportionately affecting people in developing countries. Drug resistant TB has existed in India virtually since anti-TB drugs were introduced into the country. India had the second highest total number of estimated MDR TB case (99000) in 2008, after china (100000 cases) (WHO, 2010). Materials and Methods: Patients of MDR-Pulmonary Tuberculosis at PMDT centre situated at Department of Tuberculosis and respiratory diseas{district Tuberculosis centre] UNS ASMC,JAUNPUR between june 2021 to December 2021 will be included in the study. Their psychiatric evaluation will be done at 3 months and thereafter every 6 months or whenever required. All diagnosed MDR pulmonary tuberculosis patients registered in PDMT services or whenever required is included. Other co-morbidities like HIV, chronic obstructive airways disease, diabetes mellitus and hepatitis which can cause psychosis due to any obvious cause other anti tubercular drugs or disease were excluded. Results: Most of the patients were in 20-30 years group. Number of patients were quite less from 40-70 years age group. There were more males in the groups between age groups between 12-40 years. The minimum age of patient is 10 years. The maximum age of the patient was 70 years. The mean age of patients was 28.68. 12 patients develop psychiatry symptom during treatment among them 65.4% had BMI of 14. Four patients that is 33% have BMI 18.5. It is possible that more psychiatric patients with low BMI could be due to higher concentration of drug in body. This issue has only supported but not been investigation. Conclusion: Eight patients had pre anti-tubercular treatment psychiatric problems. Four had depression, three had anxiety and one had psychosis. Twelve patients developed psychiatric symptoms after starting anti-tuberculosis treatment for drug resistance TB. All the patients had these symptoms during first three months of starting DRTB treatment. Psychiatric illness with treatment of psychiatric disease along with drug resistant TB treatment did not become hindrance to DRTB treatment. Psychiatric illness as co-morbidity with drug resistant TB had more nonworking patients as compared DRTB patients with psychiatric co-morbidity (78.1% vs 36.7%).

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