Abstract

Endometrial cancer is the most common malignancy of women in developed countries, and its incidence is rising among pre- and postmenopausal women. The major risk factor for endometrial carcinoma (EC) is the presence of a clinical scenario associated with an excess of endogenous or exogenous estrogen without adequate opposition by a progestin. Obesity, a global health problem, has been identified as the most important risk factor for hypertension and diabetes. Obese persons have a significantly higher risk of hypertension and type 2 diabetes Many studies has shown that common pathophysiology is shared by diabetes and hypertension which has direct link with obesity. Material and method: This is a prospective study done at Guru Gobind Singh Medical college and Hospital, Faridkot from June 2019 to June 2021. A total of 70 patients with biopsy proven endometrial carcinoma were enrolled in this study. Results: In this study, it is found that maximum women having carcinoma endometrium belongs to mean age of 54.52+-9.57 years.About 88.57% were having history of post menopausal bleeding.BMI is more than 30 in 60% of subjects. 24.2% women had hypertension, 21.4% had triad of hypertension, diabetes and obesity,20% had diabetes and 17.7% had both diabetes and hypertension. Conclusion: Obesity, diabetes and hypertension are the metabolic triad of endometrial cancer. The results of this study strongly suggest that the metabolic syndrome and its individual components (BMI, glucose and triglyceride concentrations, and hypertension) are important contributors in the development of endometrial carcinoma.

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