Abstract

This study was undertaken in a teaching hospital in Kolkata to use Vasoactive Inotropic Score (VIS) as outcome predictor in fluid refractory septic shock in children admitted in PICU. Methodology: A prospective study conducted in the Department of Paediatrics of Dr. B C Roy Post Graduate Institute of Paediatric Sciences, Kolkata, India from August 2018 to June 2020. 360 Children between the age of 12 month to 12 years were included in the study. Categorical variables were expressed as difference of mean VIS score between dead and survived which was primary outcome using Student t test and correlation between VIS score and length of stay (LOS), which was secondary outcome for the study, was studied using Pearson’s correlation coefficient. Results: Present study showed mean VIS 6 hr was 41.10 among dead patient and in survived patients it was 28.30. This difference of mean was statistically significant (p<0.0001). Mean VIS 24 hr was 69.56 among dead and in survived patients the mean VIS 24 hr was 45.79 and this was statistically significant (p<0.0001). Mean VIS 48 hr was 91.03 among expired and 45.99 among survived patients and again this was statistically significant (p<0.0001). Conclusions: Mean VIS scores at 6 hr, 24 hr and 48 hr was higher in children who died as compared to children who survived and the difference in mean was statistically significant (p<0.001) in resource poor setting with high mortality in fluid refractory septic shock. VIS score can provide prediction of outcome in septic shock, especially in the settings with high mortality and poor resource.

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