Abstract

Background: Uterine carcinosarcoma (UCS) represents a rare and aggressive form of uterine cancer, traditionally classified within sarcomas but now recognized due to its monoclonal origins as a de-differentiated carcinoma. This case study focuses on a rare presentation of UCS, emphasizing the importance of comprehensive diagnostic and therapeutic strategies. Case Presentation: We describe the case of a 59-year-old post-menopausal woman who presented with foul-smelling vaginal discharge, bleeding, fever, and significant weight loss. Physical examination revealed a large abdominal mass, suggestive of advanced uterine cancer. Imaging and surgical findings supported a diagnosis of UCS. The patient underwent a successful staging laparotomy, including hysterectomy and omentectomy. Histopathology confirmed a Stage 3A endometrial carcinosarcoma with extensive myometrial invasion and lymph node involvement. Post-operative management included multiple cycles of radiation therapy, which significantly improved her quality of life. Conclusion: This case highlights the importance of suspicion and prompt intervention in patients presenting with symptoms indicative of UCS. Early and aggressive management can lead to improved patient outcomes, emphasizing the need for awareness and expertise in handling such rare cases.

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