Abstract

Background: Complex intracranial neoplasms make diagnosis and treatment difficult. MRI, MRS, and perfusion imaging are essential diagnostic methods that provide precise tumor pathology insights. Objective: This study aims to evaluate the effectiveness and diagnostic precision of combining MRI, MRS, and perfusion imaging in the characterization and management of intracranial neoplasms. Methods: A prospective observational research involved 50 suspected intracranial neoplasms. A complete MRI procedure included conventional sequences, MRS, and perfusion imaging. Imaging data were compared to histopathology results, the reference standard, to evaluate diagnostic accuracy. Results: The study findings indicate high diagnostic accuracy for the combined imaging approach: MRI with contrast demonstrated a sensitivity of 90% and specificity of 80%, MRS showed a sensitivity of 88% and specificity of 85%, and perfusion imaging recorded a sensitivity of 92% and specificity of 82%. These techniques were particularly effective in distinguishing between different tumor types and grades, thereby aiding in appropriate treatment planning and management.

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