Abstract

Chemical, physical, microbiological, thermal, or immunological damage to the tissue can result in a wound, which is defined as the cellular and anatomic disturbance of a tissue. Healing a wound is the process of restoring a damaged tissue's structure and functionality to something close to its pre-wound state. After an injury, an inflammatory reaction takes place, and the cells below the dermis (the deepest layer of skin) start to produce more collagen (connective tissue). The epithelial tissue, or the outer skin, regenerates later. Inflammation, proliferation, and remodeling are the three phases of wound healing. There is a lot of potential for using plants to treat and mend wounds. Many plant extracts, which contain beneficial compounds like triterpenes, alkaloids, polyphenols, flavonoids, tannins, saponins, anthraquinones, and other biomolecules, promote the recovery of wounds. In the following research, the wound-healing efficacy of Polyphenolic fraction of Strychnos nux vomica was evaluated in excision and incision wound models. The parameters studied include rate of wound contraction, period of complete epithelialization, and tensile strength of incision wound. The Polyphenolic fraction of Strychnos nux vomica seed was found to possess significant wound-healing activity, which was evidenced by decrease in the period of epithelialization, increase in the rate of wound contraction and skin-breaking strength. The present study has demonstrated that the Polyphenolic fraction of Strychnos nux vomica seeds have properties that render them capable of promoting accelerated wound-healing activity compared with placebo control.

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