Abstract

Laryngoscopy and endotracheal intubation are frequently linked to hypertension and tachycardia because of the sympathoadrenal stimulation. To combat the pressor response several medications like local anaesthetic, B blockers and opioids. Alpha 2 agonist, Dexmedetomidine (1ug/kg) has been used as premedication 10minutes prior to induction of general anaesthesia in order to assess the pressor response of laryngoscopy and endotracheal intubation. Material and Methods: After ethical clearance 60 patients aged 18- 60 years old were randomised and divided into two groups, Group A(n=30) and group B(n=30). Group A received IV normal saline 20ml and group B received IV Dexmedetomidine, 1μg/kg diluted in 20ml of normal saline which was administered over 10 minutes and started 10 minutes prior to induction of general anaesthesia. Hemodynamic parameters were were recorded at preinduction, after induction of anaesthesia, HR, SBP, DBP and MAP were recorded at. base line (T0) after 10 minutes of the administration of the study drug (T1), after 3 minutes of the administration of the neuromuscular blocker T2, T3, T4, T5, T6, T7 and T8 recorded after 1min,2 min,3 min,5min,10min,15min and 20min after intubation. Results: There was significant difference in heart rate, systolic, diastolic and mean blood pressre at T1, T2, T3, T4, T5, T6, T7 and T8. (P<0.05). There was significant decrease in hemodynamic parametres at different time interval post laryngoscopy and induction of general anaesthesia. Conclusion: The pressor response to tracheal intubation and laryngoscopy was observed to be successfully attenuated by dexmedetomidine (1 μg/kg) IV, given 10 min before induction, with no major adverse effects.

Description

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